Metabolic Maintenance SAMe + Cofactors 200 mg 60 Caps
Metabolic Maintenance SAMe + Cofactors 200 mg 60 Caps

SAMe + Cofactors 200 mg 60 Capsules

$229.95 AUD

Key Benefits

  • Supports methylation steps tied to neurotransmitter synthesis.
  • Folate/B12/B6/TMG help recycle homocysteine efficiently.
  • Aids conjugation pathways and detox physiology.
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Mood, Methylation & Joint Comfort — SAMe 200 mg with Activated B Cofactors


Target the full methylation picture. SAMe 200 mg pairs with activated B-vitamin cofactors (e.g., methylfolate, methyl B12, P-5-P, riboflavin-5-phosphate) and donors such as TMG to support neurotransmitter balance, healthy homocysteine, joint comfort and liver pathways.

  1. Mood & motivation: Supports methylation steps tied to neurotransmitter synthesis.
  2. Homocysteine balance: Folate/B12/B6/TMG help recycle homocysteine efficiently.
  3. Liver methylation: Aids conjugation pathways and detox physiology.
  4. Joint comfort: SAMe has evidence for cartilage and mobility support.
  5. Energy & clarity: Methylation support for everyday cognitive performance.
  • 200 mg SAMe + cofactors: Matched nutrients for a complete methylation stack.
  • Activated B forms: Methylfolate, methylcobalamin, P-5-P, and R-5-P (see label).
  • Stabilized SAMe: e.g., disulfate tosylate (confirm exact salt on your label).
  • Clean excipients: Practitioner-grade formula with minimal additives.


Vitamin B6 (4 mg as pyridoxal 5’ phosphate), Folate (666 mcg DFE; 400 mcg from L-5-methylfolate, calcium salt), Vitamin B12 (1000 mcg as methylcobalamin), Calcium (54 mg as calcium carbonate), Magnesium (20 mg as magnesium citrate), SAMe (400 mg from 888 mg S-adenosyl-L-methionine disulfate p-toluenesulfonate, calcium chloride, calcium oxide).

One to two (1-2) capsules daily between meals, or as directed by a healthcare professional.


Typically minimal (e.g., vegetarian capsule [hypromellose], microcrystalline cellulose, silicon dioxide, L-leucine). Please verify on label.

  • Generally free from gluten, dairy, soy and GMOs. Confirm on label.
  • Mood medications: Consult your healthcare professional if using SSRIs, MAOIs or other antidepressants.
  • Bipolar disorder: Use only under medical supervision.
  • May cause GI upset in some; reduce dose or take with a small snack if needed.
  • Pregnancy/breastfeeding: seek professional advice.
  • Always read the label and follow directions for use. Supplements should not replace a balanced diet.


Store below 25°C in a cool, dry place away from direct sunlight. Keep out of reach of children.